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| Registros recuperados: 22 | |
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| Reyser, Thibaud; To, Tung H.; Egwu, Chinedu; Paloque, Lucie; Nguyen, Michel; Hamouy, Alexandre; Stigliani, Jean-luc; Bijani, Christian; Augereau, Jean-michel; Joly, Jean-patrick; Portela, Julien; Havot, Jeffrey; Marque, Sylvain R. A.; Boissier, Jérôme; Robert, Anne; Benoit-vical, Françoise; Audran, Gérard. |
| Malaria and schistosomiasis are major infectious causes of morbidity and mortality in the tropical and sub-tropical areas. Due to the widespread drug resistance of the parasites, the availability of new efficient and affordable drugs for these endemic pathologies is now a critical public health issue. In this study, we report the design, the synthesis and the preliminary biological evaluation of a series of alkoxyamine derivatives as potential drugs against Plasmodium and Schistosoma parasites. The compounds (RS/SR)-2F, (RR/SS)-2F, and 8F, having IC50 values in nanomolar range against drug-resistant P. falciparum strains, but also five other alkoxyamines, inducing the death of all adult worms of S. mansoni in only 1 h, can be considered as interesting... |
| Tipo: Text |
Palavras-chave: Alkoxyamine; Alkylation; Heme; Malaria; Radical chemistry; Schistosomiasis. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00648/76024/76920.pdf |
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| Crego-vicente, Beatriz; Fernández-soto, Pedro; Febrer-sendra, Begoña; García-bernalt Diego, Juan; Boissier, Jérôme; Angora, Etienne K.; Oleaga, Ana; Muro, Antonio. |
| Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions caused by different species of parasitic flatworms of the genus Schistosoma. The emergence of natural hybrids of schistosomes indicate the risk of possible infection to humans and their zoonotic potential, specifically for Schistosoma haematobium and S. bovis. Hybrid schistosomes have the potential to replace existing species, generate new resistances, pathologies and extending host ranges. Hybrids may also confuse the serological, molecular and parasitological diagnosis. Currently, LAMP technology based on detection of nucleic acids is used for detection of many agents, including schistosomes. Here, we evaluate our previously developed... |
| Tipo: Text |
Palavras-chave: LAMP; Schistosomiasis; Schistosome hybrids; Schistosoma haematobium; Schistosoma bovis; Molecular diagnosis; Species-specific LAMP; Genus-specific LAMP. |
| Ano: 2021 |
URL: https://archimer.ifremer.fr/doc/00686/79840/82659.pdf |
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| Mintsa Nguema, Rodrigue; Mavoungou, Jacques F.; Ngou-milama, Krystina Mengue Me; Mamfoumbi, Modeste Mabicka; Koumba, Aubin A.; Lamine, Mariama Sani; Diarra, Abdoulaye; Asseko, Ghislaine Nkone; Mourou, Jean R.; Akotet, Marielle K. Bouyou; Mone, Helene; Mouahid, Gabriel; Atsame, Julienne. |
| In order to follow the Preventive Chemotherapy (PC) for the transmission control as recommended by WHO, Gabon initiated in 2014 the mapping of Schistosomiasis and Soil Transmitted Helminthiasis (STH). Here, we report the results of the Northern and Eastern health regions, representing a third of the land area and 12% of its total population. All nine departments of the two regions were surveyed and from each, five schools were examined with 50 schoolchildren per school. The parasitological examinations were realized using the filtration method for urine and the Kato-Katz technique for stool samples. Overall 2245 schoolchildren (1116 girls and 1129 boys), mean aged 11.28 +/- 0.04 years, were examined. Combined schistosomiasis and STH affected 1270 (56.6%)... |
| Tipo: Text |
Palavras-chave: Schistosomiasis; Soil-transmitted-helminthiasis; Mapping; Preventive chemotherapy; Transmission control; Gabon; Central Africa. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00660/77212/78691.pdf |
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| Lima, Mariana G.; Montresor, Lângia C.; Pontes, Joana; Augusto, Ronaldo De C.; Silva, Jairo Pinheiro Da; Thiengo, Silvana C.. |
| Sympatric snail populations have been kept in the laboratory since the isolation of the parasite from the field. To evaluate the influence of the intermediate host in the infectivity of S. mansoni, this allopatric strain was compared to two sympatric strains, from different geographical origins, and with different time of maintenance in the laboratory. Snail–trematode compatibility was accessed for a total of nine possible combinations (three snail populations, three schistosome strains), using different charges of parasite: 1, 5, 10, and 15 miracidia/snail. Each S. mansoni strain was characterized according to its infectivity phenotype that reflects the efficiency of their infection mechanism and all B. glabrata populations were characterized according to... |
| Tipo: Text |
Palavras-chave: Snail-trematode; Host-parasite; Interaction; Compatible; Incompatible; Infectivity; Resistance; Schistosomiasis. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00489/60084/63419.pdf |
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| De Carvalho Augusto, Ronaldo; Duval, David; Grunau, Christoph. |
| Evidence of how environmental cues affect the phenotypes of, and compatibility between Schistosoma mansoni and their hosts come from studies in environmental parasitology and research on host diet and chemotherapeutic treatment. Schistosomes deal with a multitude of signals from the water environment as well as cues that come from their hosts, particularly in response to molecules that serve to recognize and destroy them, i.e., those molecules that arise from their hosts' immune systems. These interactions shape, not only the parasite's morphology, metabolism and behavior in the short-term, but also their infection success and development into different stage-specific phenotypes later in their life cycle, through the modification of the parasite's... |
| Tipo: Text |
Palavras-chave: Schistosomiasis; Environmental cues; Inheritance systems; Imune response; Host-para site interactions. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00508/61941/66028.pdf |
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| Mulero, Stephen; Boissier, Jérôme; Allienne, Jean‐françois; Quilichini, Yann; Foata, Joséphine; Pointier, Jean‐pierre; Rey, Olivier. |
| Under ongoing climate changes, the development of large‐scale monitoring tools for assessing the risk of disease emergence constitutes an urging challenge. This is particularly the case for snail‐borne diseases such as the urogenital bilharziasis that emerged in Corsica and threat European countries. The expansion of this tropical disease mainly relies on the local presence of competent snail hosts such as Bulinus truncatus. Unfortunately, very little is known about the actual repartition of freshwater snails worldwide which makes new emergences difficult to predict. In this study, we developed two ready‐to‐use environmental DNA‐based methods for assessing the distribution of B. truncatus from water samples collected in the field. We used two approaches, a... |
| Tipo: Text |
Palavras-chave: Bulinus truncatus; Corsica; DdPCR; Environmental DNA; Environmental monitoring; QPCR; Schistosomiasis. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00593/70554/68723.pdf |
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| Passos-Castilho,Ana Maria; de Sena,Anne; Domingues,Ana Lucia Coutinho; Lopes-Neto,Edmundo Pessoa; Medeiros,Tibério Batista; Granato,Celso Francisco Hernandez; Ferraz,Maria Lúcia. |
| Abstract Background Hepatitis E virus (HEV) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. HEV seroprevalence in patients with Schistosoma mansoni in Brazil is unknown. We evaluated the prevalence of past or present HEV infection in schistosomiasis patients in Recife, Pernambuco, Brazil. A total of 80 patients with Schistosoma mansoni were consecutively enrolled in a cross-sectional study. Serum samples were tested for the presence of anti-HEV IgG antibodies by enzyme immunoassay (Wantai anti-HEV IgG, Beijing, China) and for the presence of HEV RNA using real time reverse transcriptase-polymerase chain reaction with primers targeting the HEV ORF2 and ORF3. Clinical and laboratory tests as well as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazil; Epidemiology; Hepatitis E virus; Schistosomiasis; Seroprevalence. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300007 |
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| De Carvalho Augusto, Ronaldo; Correa De Mello-silva, Clelia Christina. |
| Worldwide schistosomiasis remains a serious public health problem with approximately 67 million people infected and 200 million at risk of infection from inhabiting or transiting endemically active regions. Africa, South America, the Caribbean, and the Middle East are the main transmission regions of Schistosoma mansoni. The fight against transmission through the use of molluscicides is not recent and has been advocated as the only activity with the possibility of interruption of transmission in small, epidemiologically active outbreaks. Euphorbia milii var. hislopii (syn. splendens) (Des Moulins, 1826) is the most promising for use in official schistosomiasis control programs according to the WHO. In this review, we show that an understanding of some how... |
| Tipo: Text |
Palavras-chave: Schistosomiasis; Molluscicide; Control programs; Transmission control. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00660/77213/78690.pdf |
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| PEREIRA,Adriany Duarte; PINTO,Pedro Luiz Silva; CAMARGO,Juliana de Souza Almeida Aranha; SOUZA,Juliana Bianca Rocha de; AMANTE,Carlos Antônio; SOUZA,Viviane Krominski Graça de; SIMONE,Luiz Ricardo Lopes de; CAMARGO,Luís Marcelo Aranha. |
| ABSTRACT Schistossomiasis is a parasitic disease, caused by helminths of the genus Schistosoma and transmitted in Brazil by snails of the genus Biomphalaria. The municipality of Ouro Preto do Oeste, Rondônia, in the Brazilian Amazon Region, has unusually registered more than 900 cases of schistosomiasis in the last 10 years. The aim of this study was to investigate de potential of transmission of schsitosomiasis in Ouro Preto do Oeste. A total of 1,196 people in a risk area for the disease transmission were requested to answer a clinical-epidemiological survey and to collect feces samples for examination. All the samples that underwent examination resulted negative for S. mansoni. Two hundred and sixty-eight snails were collected in the locality of Ouro... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Schistosomiasis; Amazon; Transmission. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000400377 |
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| Angora, Etienne K.; Boissier, Jérôme; Menan, Hervé; Rey, Olivier; Tuo, Karim; Touré, Andre O.; Coulibaly, Jean T.; Méité, Aboulaye; Raso, Giovanna; N’goran, Eliézer K.; Utzinger, Jürg; Balmer, Oliver. |
| Schistosomiasis is a parasitic disease affecting more than 250 million people, primarily in sub-Saharan Africa. In Côte d’Ivoire both Schistosoma haematobium (causing urogenital schistosomiasis) and Schistosoma mansoni (causing intestinal schistosomiasis) co-exist. This study aimed to determine the prevalence of S. haematobium and S. mansoni and to identify risk factors among schoolchildren in the western and southern parts of Côte d’Ivoire. From January to April 2018, a cross-sectional study was carried out including 1187 schoolchildren aged 5–14 years. Urine samples were examined by a filtration method to identify and count S. haematobium eggs, while stool samples were subjected to duplicate Kato-Katz thick smears to quantify eggs of S. mansoni and... |
| Tipo: Text |
Palavras-chave: Côte d’Ivoire; Prevalence; Risk factors; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00508/61953/66043.pdf |
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| DAlmeida,J.; Maliska,C.; Pellegrini,P. M.; Penas,M. E.; Collares,R. A.; Cruz,M. G. A.. |
| The present study was carried out at the Army Central Hospital, Rio de Janeiro, Brazil, from September 2000 to December 2001, employing diethylenetriamine penta-acetic acid labeled with technetium-99m (99mTc-DTPA) to evaluate the renal function of nineteen symptomatic patients infected with S. haematobium during a peace mission in Mozambique. Results evidenced that the most frequent clinical manifestations were hematuria (68.4%) and low back pain (68.4%) and 73.7% patients had altered dynamic renal scintigraphy expressed by an increase in the excretory phase independently of the symptoms duration; furthermore, none of them had mechanical obstructive pattern. Schistosoma haematobium glomerulopathy could be considered a pathological finding without... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Schistosomiasis; Schistosoma haematobium; Renal radionuclide imaging; Brazilian patients; 99mTc-DTPA. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300010 |
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| Huot, Camille; Clerissi, Camille; Gourbal, Benjamin; Galinier, Richard; Duval, David; Toulza, Eve. |
| Planorbidae snails are the intermediate host for the trematode parasite of the Schistosoma genus, which is responsible for schistosomiasis, a disease that affects both humans and cattle. The microbiota for Schistosoma has already been described as having an effect on host/parasite interactions, specifically through immunological interactions. Here, we sought to characterize the microbiota composition of seven Planorbidae species and strains. Individual snail microbiota was determined using 16S ribosomal DNA amplicon sequencing. The bacterial composition was highly specific to the host strain with limited interindividual variation. In addition, it displayed complete congruence with host phylogeny, revealing a phylosymbiosis pattern. These results were... |
| Tipo: Text |
Palavras-chave: Microbiota; Phylosymbiosis; Metabarcoding; Planorbid snails; Tripartite interactions; Schistosomiasis. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00606/71807/70295.pdf |
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| Registros recuperados: 22 | |
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